The term Great Schism may refer to one of several events in Christianity:
- The East-West Schism (formally in 1054), between Western Roman Catholic and Eastern Orthodox Christianity.
- The Western Schism (1378 to 1417) within the Roman Catholic Church, related to the popes in Avignon versus those in Rome.
- The Old Believers schism (1666–1667) in the Russian Orthodox Church.
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