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St. Eustathius redirects here; see also Saint Eustace.

Eustathius of Antioch, sometimes surnamed the Great, was a bishop and patriarch of Antioch in the 4th century.

He was a native of Side in Pamphylia. About 320 he was bishop of Beroea, and he became patriarch of Antioch shortly before the Council of Nicaea in 325. In that assembly he distinguished himself zealously against the Arians, though the Allocutio ad Imperatorem with which he has been credited is hardly genuine.

His anti–Arian polemic against Eusebius of Caesarea made him unpopular among his fellow bishops in the East, and a synod convened at Antioch in 330 deposed him for adultery,[1] which was confirmed by the emperor.

For instance, in the dispute with Eustathius of Antioch, who opposed the growing influence of Origen and his practice of an allegorical exegesis of scripture, seeing in his theology the roots of Arianism, Eusebius, an admirer of Origen, was reproached by Eustathius for deviating from the Nicene faith, who was charged in turn with Sabellianism. Eustathius was accused, condemned, and deposed at a synod in Antioch. The people of Antioch rebelled against this action, while the anti-Eustathians proposed Eusebius as the new bishop, but he declined. He ordained a Bishop, Mor Joseph for Edessa. Later that Bishop went to India with Thomas of Cana and 72 families. He was banished to Trajanopolis in Thrace, where he died, probably about 337, though possibly not until 360.

The only complete work by Eustathius is the De Engastrimytho contra Origenem (ed. by A. Jahn in Texte und Untersuchungen, ii. 4; J. H. Declerck in Corpus Christianorum - Series Graeca no. 51, 2002), which discusses the episode of the Witch of Endor in 1 Samuel. Other fragments are enumerated by G. F. Loofs in Herzog-Hauck’s Realencyklopädie.

The Commentary on the Hexameron attributed to him in the manuscripts is not authentic.


  1. Philostorgius, in Photius, Epitome of the Ecclesiastical History of Philostorgius, book 2, chapter 7.
Preceded by
Paulinus of Tyre
Patriarch of Antioch
324—337 or 360
Succeeded by

ca:Eustaci d'Antioquia hu:Antiochiai Eusztathiosz ru:Евстафий Антиохийский uk:Святитель Євстахій